These observations are consistent with studies showing a role for HNF1B in the regulation of mitochondrial metabolism in ovarian cancers and in renal cells [32,52], and with the role of NRFs in the regulation of mitochondrial biogenesis and the transcriptional regulation of Tfb2m, Tfam, and Tfb1m (Figure 5, Figure 10) [28,29,[53], [54], [55]]. The gene discussed is TFB2M; the disease is ovarian cancer.