IL1A and migraine disorder: These genotypes produce low amounts of cytokine,19and this effect on the aura might be due to the reduced physiological effect of IL-1α, which is produced and expressed in the membrane of various cell types, including brain astrocytes, during homeostatic balance.11A small study by Boćkowski et al.12involving 21 children and adolescents found higher levels of IL-1α in migraine with aura.