Several cytokines, including tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β) and interleukin-6 (IL-6), have been associated with the pathophysiology of migraine, as increased values of these cytokines have been observed in individuals with this condition.6, 7, 8, 9Interleukin-1 alpha (IL-1α) is a proinflammatory cytokine that exists constitutively as a precursor in various healthy tissues. The gene discussed is TNF; the disease is migraine disorder.