We integrated analyzed the function of P4HA3 among 33 types of cancers, and found that P4HA3 was associated with proliferation markers (PCNA and MKI67), EMT markers (VIM, TWIST1, SNAI1, SNAI2, FN1 and CDH2), extracellular matrix (ECM) markers (MMP9, MMP7, MMP2 and MMP14). Here, TWIST1 is linked to cancer.