P4HA3 and cancer: Compared to that normal tissues, P4HA3 mRNA expression was upregulated in BRCA, CHOL, COAD, ESCA, GBM, HNSC, KIRC, LUAD, LUSC, PCPG, PRAD, READ, STAD, THCA, ACC, LAML, PAAD, TCGT, and UCS tissues, suggesting that P4HA3 might function as an oncogenic role in the occurrence and development of diverse cancers (Fig 1A and 1B).