CD4 and bacterial infectious disease: As for Th17 immunity responsible for clearing bacterial infection, our results demonstrate a dispensable role for Lgals3 in clearing C. rodentium infection, which is consistent with a previous observation.44 Interestingly, although we observed upregulation of Lgals3 in CD4+ T cells during EAE development, Lgals3 was not upregulated in colonic CD4+ T cells in response to C. rodentium infection, suggesting a tissue-specific function for Lgals3 and supports the selective requirement for Lgals3 in EAE development but not in C. rodentium infection clearance.