INS and obesity due to melanocortin 4 receptor deficiency: We recognize some limitations in the current study: 1) It was not possible to carry out hormonal analysis of insulin, glucagon, ghrelin, and leptin, which are important for discussing metabolic adaptation in obesity and the role of HIIT and H. abdariffa; 2) As several obesity-induced changes occur in the liver, morphological analysis of a cross-sectional area and fat droplets of the liver could indicate the role of the two non-pharmacological strategies as prevention and/or treatment tools.