However, both ectopic fat accumulation and adipose tissue expansion stimulate the secretion of pro-inflammatory adipokines such as leptin, interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α) and inhibit the release of anti-inflammatory products such as adiponectin, thus modifying metabolic and inflammatory processes, and triggering metabolic changes such as hypertension, hyperinsulinemia, dyslipidemia, diabetes, and other conditions (6). This evidence concerns the gene TNF and hyperinsulinism.