However, blood vessels also express the CysLTR2,20,38 with its prominent role in retinal edema and ischemia-induced retinal pathogenesis39; it may be imperative to study the CysLTR1 and CysLTR2 receptor knockdowns in independent experiments, as well as in combination, which might better define the molecular pathways downstream of montelukast in DR. This evidence concerns the gene CYSLTR1 and ischemia.