Consistent with this, siRNA knockdown of cFLIP sensitizes resistant human U343 GBM cells to SMC and TNF-α or TRAIL treatment [380], suggesting overlapping but slightly different roles in GBM death ligand resistance between PEA-15 and cFLIP, or cell line differences in expression; U343 cells express low PEA-15 and the kinase CAMKII [78]. The gene discussed is CFLAR; the disease is glioblastoma.