CASP8 and neoplasm: However, high CASP8 expression has been associated with worse survival given sublethal actions of CASP8 in tumor growth, angiogenesis and cytokine secretion via alterations to NF-κB signaling and nuclear localization, as well as in migration via enhancements to Calpain cysteine protease activities [381], which have key roles in GBM invasion and apoptosis resistance [382–385].