Comparing the N6AMT1-dependency profile across the 1,100 cancer cell lines with the dependency profiles of 15,677 nonessential genes, we found that N6AMT1 correlated best with nuclear-encoded genes coding for mitochondrial proteins [MitoCarta3.0 genes (34)] (Fig. 1 B and C, SI Appendix, Fig. S1B, and Datasets S1 and S2). This evidence concerns the gene HEMK2 and cancer.