FZD5 and Brachycephaly: Finally, this marks the first report of an individual presenting with short stature, brachycephaly, facial asymmetry, telecanthus, epicanthus, and brachydactyly of the hands associated with FZD5. To date, FZD5 expression has only been reported in the eyes and brain during embryonic development (Liu and Nathans 2008; Nikaido et al. 2013).