In the KCNQ1 gene, we identified six rare missense variants related to SQTS, two associated with isolated SQTS (p.Phe279Ile and p.Ala287Thr) (Schneider et al. 2021), and four concomitant to AF (p.Val141Met, p.Arg259His, p.Phe299Val and p.Val307Leu) (Hong et al. 2005; Mazzanti et al. 2014; Moreno-Manuel et al. 2024; Wu et al. 2015). Here, KCNQ1 is linked to Familial short QT syndrome.