The proportion of patients with a diagnosis of type 2 diabetes who were treated with insulin (Fig. 4d) increased from 8.9% in 2012–2013 to 37% in 2018–2019 and 31% in 2020–2021, and the proportion treated with oral agents (Fig. 4e) increased from 51% in 2012–2013 to 57% in 2020–2021. This evidence concerns the gene INS and type 2 diabetes mellitus.