Ultimately, only bi-allelic variants in DNAH3 (NG_052617.1, NM_017539.2, NP_060009.1) remained, suggesting as the pathogenic variants responsible for the infertility of the patients: a compound heterozygous mutation of c.3590C>T (p.Pro1197Leu) and c.3590C>G (p.Pro1197Arg) in Patient 1, a homozygous missense mutation of c.4837G>T (p.Ala1613Ser) in Patient 2, a compound heterozygous mutation of c.5587del (p.Leu1863*) and c.10355C>T (p.Ser3452Leu) in Patient 3, and a compound heterozygous mutation of c.2314C>T (p.Arg772Trp) and c.4045G>A (p.Asp1349Asn) in Patient 4 (Figure 1A). The gene discussed is DNAH3; the disease is Infertility.