Interestingly, among genes up-regulated in BCR::ABL1+ primitive cells included the expression of established CML markers; IL2RA (CD25), DPP4 (CD26), and IL1RAP as well as LEPR (CD295) a receptor recently described as a novel marker for Lin-CD34+CD38-/low LSCs (Landberg et al., 2018). This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.