ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: To allow for accurate specification of LSPC heterogeneity without confounding effects generated from cell-type-irrelevant transcriptional signals related to BCR-ABL transformation per se, or inter-patient variability due to batch effects, we used Scarf projection (Dhapola et al., 2022) to map each individual CML cell to a Lin-CD34+ healthy bone marrow reference with a predefined heterogeneity.