This included a constellation of genes such as surface markers, CD81 (Quagliano et al., 2020), nucleoside diphosphate kinase with transcriptional regulatory activity, NME2 (Kar et al., 2012; Thakur et al., 2009; Thakur et al., 2014; Thakur et al., 2011; Tschiedel et al., 2012; Tschiedel et al., 2008; Yadav et al., 2014) previously implicated in CML, genes of histone family, and components of SWI/SNF chromatin remodeling complex, BRD7 (Kaeser et al., 2008), as well as genes of histone methyltransferase family, KMT3A and 5 A (Husmann and Gozani, 2019). This evidence concerns the gene NME2 and chronic myelogenous leukemia, BCR-ABL1 positive.