(B) Box plots comparing cluster proportions in optimal responders (n=4, CML patients 1–4) and treatment failures (n=2, CML patients 8–9) at diagnosis; the patients were retrospectively stratified according to BCR::ABL1IS (%) after 12 months of TKI therapy (Optimal ≤1 %), Failure >1 %. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.