Taken together, these observations suggested that although patients are heterogeneous for a given marker, BCR::ABL1+ LSCs can be consistently captured by the CD26+CD35- combination while BCR::ABL1- HSCs expressed a CD26-CD35+ immunophenotype within Lin-CD34+CD38-/low compartment in the bone marrow of CML patients. The gene discussed is CR1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.