Given the heterogeneity within normal HSCs with respect to lineage bias and clonal output (Haas et al., 2018), it is tempting to speculate that stem/progenitor cell acquiring the BCR::ABL1 oncogenic hit perhaps might be different across CML patients ensuring disparity in LSC load and characteristics. Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.