CD4 and infection: GFI1, a protein-coding gene located in 1p22.1, regulates gene expression by blocking transcription and is essential for CD4 + cell function.21KPNB1, located in 17q21.32, plays a role in NF-κB signalling, an important process for immune cell activation in response to infection or inflammation.21NPEPPS located in 17q21.32, participates in the innate immune system pathway and contributes to proteolytic events that regulate the cell cycle.