SHBG and myeloid sarcoma: We next explored the causal relationship between levels of SHBG, testosterone, and MS risk and found an overall null association (IVW SHBG OR = 1.23, 95% CI = 0.90–1.68, p = 0.19; SHBGadjBMI OR = 1.23, 95% CI = 0.94–1.60, p = 0.13; total testosterone OR = 0.89, 95% CI = 0.77–1.04, p = 0.13; bioavailable testosterone OR = 0.99, 95% CI = 0.82–1.19, p = 0.92) (Figure 2, Supplementary Table 7).