In XLRS, over 190 mutations in the Retinoschisin‐1 (RS1) gene, primarily located within the discoidin domain,[6] have been identified and are widely recognized as the primary cause of XLRS pathogenesis.[7] Despite the valuable insights gained from XLRS research using Rs1‐knockout mice,[2, 3, 4] this model does not incorporate the specific clinically relevant mutations found in patients. The gene discussed is RS1; the disease is X-linked retinoschisis.