Alzheimer’s disease (AD) and related tauopathies are characterized by the stereotypical accumulation of fibrillary aggregates primarily composed of hyperphosphorylated and truncated tau (Novak et al., 1993; Grundke-Iqbal et al., 1986; Wang et al., 2013). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.