Concerning the cancer treatment, assumptions are made that the high levels of SR ligands may induce a rapidly decreased expression of the modulator of Ras homolog gene (Rho) family G proteins (Rho GDI), which allows the activation of Rho guanosine-triphosphate (GTP) as required to transfer complexes S1R and inositol 1,4,5-trisphosphate receptor type 3 (IP3R3) and results in inhibition of ion flux, especially of Ca2+, and simultaneous deregulation of the ceramide biosynthesis pathway [62]. This evidence concerns the gene TMBIM4 and cancer.