NEFL and Niemann-Pick disease type C: In this study, we observed that, similar to recent reports,37 plasma NfL was increased in Niemann–Pick disease type C (n = 49) compared with HC (n = 56) and showed high accuracy differentiating these groups (21.73 ± 17.70 versus 6.34 ± 4.19 pg/mL, respectively, AUC: 0.84, Fig. 2B and C).