B1MDI3 is a tRNA guanine-methyltransferase, P56817 is BACE1, a beta-secretase relevant to the development of Alzheimer’s disease [27], P17931 is galectin-3, a galactose-specific lectin involved in cancer [28], Q8ULI9 is the human immunodeficiency virus 1 (HIV-1) protease, and P01116 is the GTPase K-Ras, a key cancer target. Here, BACE1 is linked to early-onset autosomal dominant Alzheimer disease.