Although estrogen is believed to be beneficial to the human body and exerts protective effects on stroke through various pathways such as anti-inflammation, anti-oxidative, inhibition of platelet agglutination, and promotion of nerve growth factor expression (58), changes in hormone levels due to menarche, menopause, pregnancy, childbirth, and miscarriage can easily lead to a weakening or alteration of these effects. This evidence concerns the gene NGF and stroke disorder.