For example, green tea-derived polyphenols have been shown to dampen inflammatory cascades in IBD models by modulating the TLR4/MyD88/NF-κB signaling pathway, and dietary fibers stimulate the production of SCFAs like butyrate, which enhances gut barrier function and modulates immune responses in obesity and diabetes. This evidence concerns the gene MYD88 and obesity due to melanocortin 4 receptor deficiency.