For example, green tea-derived polyphenols have been shown to dampen inflammatory cascades in IBD models by modulating the TLR4/MyD88/NF-κB signaling pathway, and dietary fibers stimulate the production of SCFAs like butyrate, which enhances gut barrier function and modulates immune responses in obesity and diabetes. The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.