In multivariate analysis, except for GLIM-defined malnutrition (p < 0.001), age (p = 0.001), TNM stage (p = 0.001), handgrip strength (p = 0.028), and serum albumin level (p = 0.042) were identified as independent prognostic factors for OS in patients who underwent radical colectomy or proctectomy. The gene discussed is ALB; the disease is nutritional deficiency disease.