Therefore, unconjugated hyperbilirubinemia can result from increased production from increased heme breakdown (e.g., hemolysis, dyserythropoiesis), impaired liver uptake of bilirubin (e.g., liver congestion, portosystemic shunt, drugs, etc.)and impaired conjugation of bilirubin due to genetic mutations in the UGT1A1 gene (e.g., Gilbert’s syndrome, Crigler-Najjar syndrome) [1]. Here, UGT1A1 is linked to Gilbert syndrome.