Individuals with class-1 variants have a residual G6PD activity of less than 10% of normal accompanied by chronic non-spherocytic hemolytic anemia or acute exacerbations, class-II variants have similarly low G6PD activity but have no symptoms in the steady state, class-III variants exhibit 10-60% activity with no symptoms in the steady state, and class-IV and class-V variants have 100% and above 100% activity and no symptoms [3,4]. This evidence concerns the gene G6PD and anemia, nonspherocytic hemolytic.