ELOC (formerly TCEB1)-mutated RCC, SMARCB1 (INI1)-deficient RCC, TFE3-rearranged RCCs, ALK-rearranged RCCs, and TFEB-rearranged and TFEB-amplified RCCs, are examples of molecularly characterized RCCs [1]. The gene discussed is SMARCB1; the disease is renal cell carcinoma.