MSH2 and gastric cancer: The cumulative risk of individuals developing GC at 60, 70, and 75 y was 18.2% (MLH1 18.9%, MSH2 18.0%), 31.3% (MLH1 36.1%, MSH2 18.0%), and 37% (MLH1: 42.5%, MSH2: 18%), respectively (Figure 3A).