Angiogenesis inhibitors targeting any component of the VEGF pathway, including VEGF inhibitors (VEGFi), VEGF receptor inhibitors (VEGFRi), and small molecule complex kinase inhibitors, can inhibit endothelial proliferation and disrupt the vascular supply of nutrients and oxygen, thereby achieving the goal of curbing tumor growth and metastasis (11, 12). This evidence concerns the gene VEGFA and neoplasm.