Previously, we demonstrated that LPG expressed by metacyclic promastigotes induces DKK1 production from platelets through the activation of TLR2 within 72 hours post-infection (19), and DKK1 released promoted leukocyte-platelet aggregation, which is essential for early trafficking of neutrophils and polarization of immune responses in pathological type 2 cell-mediated inflammation (19, 31). Here, TLR2 is linked to infection.