This observation is in accordance with our previous studies, which showed that DKK1 upregulates LPA and leukocytes in blood obtained from wild-type parasite-infected mice, and pretreatment with a DKK1 inhibitor prior to infection with L. major reduced the elevation of LPA formation, as well as subsequent neutrophil infiltration to the draining lymph node (31). The gene discussed is DKK1; the disease is infection.