CD4 and telomere syndrome: Significantly lower frequencies of Th2 cells (42.2% of CD4 T cells, IQR: 25.9–52.6, N = 55) and increased frequencies of Th17 cells (13.2% of CD4 T cells, IQR: 10.1–19, N = 55) were observed in STS patients when compared with HD controls (53.1% of CD4 T cells, IQR: 46.4–63.6, N = 45, adj p = 001292; 7.2% of CD4 T cells; IQR: 6.1–11.6, N = 45, adj p = 000194; respectively), while no differences were observed for Th1 nor Treg cells (Supplementary File S9B).