CD4 and telomere syndrome: The maturation state of CD4 T cells was evaluated, and it was observed that there was a decreased relative frequency of naïve CD4 T cells (9.4% of CD4 T cells, IQR: 5.2–21.8, N = 55) in STS patients than in HD controls (34.3% of CD4 T cells, IQR: 17.1–43, N = 45, adj p < 0.000001) (Supplementary File S9A).