CD4 and telomere syndrome: Moreover, besides no alterations in the relative frequency of T cells (Supplementary File S7B), it was observed a significant reduction in the absolute and relative frequency of CD4 T cells (0.32 cells/<L, IQR: 0.17–0.57, N = 49; 46.3% of T cells, IQR: 36.2–60.6, N = 55; respectively) in STS patients comparatively with HD controls (0.9 cells/<L, IQR: 0.68–1.03, N = 45, adj p < 0.000001; 59.8% of T cells, IQR: 55.3–67.8, N = 45, p = 0.000963; respectively) (Figures 1F, G; Supplementary File S8).