CD28 and telomere syndrome: The gene expression analysis revealed decreased expression levels of CD28 and IL2RA in STS patients (0.770 CNRQ, IQR: 0.331–2.681, N = 55; 0.583 CNRQ, IQR: 0.277–1.709, N = 54) comparatively with HD controls (3.059 CNRQ, IQR: 1.497–4.639, N = 45, adj p = 0.000116; 2.429, IQR: 1.638–3.510, N = 45, adj p = 0.000011; respectively) (Figure 1H).