TIMD4 and telomere syndrome: In the analysis of IRSF, factors such as IL-2, IL-5, IL-10, IL-17A, IFN-γ, MMP1, bNGF, TLSP, VISTA, TIMD-4, PVR, and CTLA-4 were indicated as risk factors, while an increased level of soluble ICOS-L was associated with protection in STS patients (Figure 4).