ICOSLG and telomere syndrome: In whole blood gene expression analysis, lower expression levels of CD27, CD40LG, and ICOSLG (0.586 CNRQ, IQR: 0.208–1.843, N = 55; 0.600 CNRQ, IQR: 0.364–1.651, N = 55; 0.400 CNRQ, IQR: 0.209–2.952, N = 49; respectively) were observed in STS patients comparatively with HD controls (3.059 CNRQ, IQR: 1.497–4.649, N = 45, adj p < 0.000001; 1.899 CNRQ, IQR: 1.018–2.608, N = 45, adj p = 0.004186; 3.060 CNRQ, IQR: 1.776–4.430, N = 45, adj p = 0.00001; respectively) (Figure 1D).