TIMD4 and telomere syndrome: Moreover, the analysis of the IRSF revealed increased levels of TIMD-4 in plasma samples from STS patients (635.9 pg/mL, IQR: 411.1–1603.8, N = 20) compared with HD controls (261.5 pg/mL, IQR: 150.5–418.9, N = 19, adj p = 0.008118) (Figure 2G).