PRF1 and telomere syndrome: Additionally, through the correlation analysis of CD8 T cells and CD56dim NK cells with the gene expression levels of PRF1, GZMB, and KLRK1 in STS patients, it was observed a significant positive correlation of CD56dim NK cells with PRF1 (Spearman r = 0.273, p = 0.0435) and EMRA CD8 T cells with PRF1 (Spearman r = 0.312, p = 0.0203), GZMB (Spearman r = 0.266, p = 0.0496), and KLRD1 (Spearman r = 0.336, p = 0.0122) (Figure 3F).