CD8A and telomere syndrome: The analysis of the peripheral blood and plasma samples showed a significant increase in the relative frequency of CD8 T cells (45.7% of T cells, IQR: 32.4–57.1, N = 55) in STS patients when compared with HD controls (32.9% of T cells, IQR: 26–37.8, N = 45, adj p = 0.001186) (Figure 3A), while no differences were observed for absolute frequency (Supplementary File S8A).