Gene expression analysis of whole blood samples showed that STS patients had significantly decreased levels of the IRG PRF1 (0.484, IQR: 0.185–2.049, N = 55), GZMB (0.515 CNRQ, IQR: 0.351–1.457, N = 55), and KLRK1 (0.545 CNRQ, IQR: 0.318–2.047, N = 55) comparatively to HD controls (2.365 CNRQ, IQR: 1.675–3.772, N = 45, adj p = 0.000188; 1.705, IQR: 1.312–2.453, N = 45, adj p = 0.000525; 2.098 CNRQ, IQR: 1.580–3.354, N = 45, adj p = 0.000965; respectively) (Figure 3D). The gene discussed is PRF1; the disease is telomere syndrome.