Although the favorable effect of GH in improving oxygenation in HPS has only been observed in those secondary to hypopituitarism (2, 3, 5, 6, 10), it is worthwhile to explore the potential effectiveness of GH in patients with HPS of alternative etiologies, considering recent reports indicating that GH replacement therapy may have a positive impact on non-alcoholic fatty liver disease (21). Here, GH1 is linked to hypopituitarism.