Unlike in mild COVID-19, the severe cases of COVID-19 that were admitted to intensive care units (3–6) and showed the involvement of insulin-like growth factor receptor I (IGF-IR), enhanced NOTCH signaling, along with altered expression levels of Bcl2, AKT1, and MAPK8 that can lead to endocrine resistance through various intricate mechanisms (Figure 5). This evidence concerns the gene AKT1 and COVID-19.