Unlike in mild COVID-19, the severe cases of COVID-19 that were admitted to intensive care units (3–6) and showed the involvement of insulin-like growth factor receptor I (IGF-IR), enhanced NOTCH signaling, along with altered expression levels of Bcl2, AKT1, and MAPK8 that can lead to endocrine resistance through various intricate mechanisms (Figure 5). The gene discussed is BCL2; the disease is COVID-19.