Pharmacokinetic: inhibition of CYP3A4 and CYP2C19 by sertraline increased concentration and side effects of CBD (metabolized by CYP3A4 and CYP2C9)Pharmacokinetic: inhibition of CYP2C19 and CYP2C9 and p-glycoprotein by CBD increased concentration of sertraline (metabolised by CYP2C19 and CYP2C9 and transported by p-glycoprotein)Addition of side effects: CBD may induce gastrointestinal symptoms, including diarrhoea 20% of patients treated with sertraline present diarrhoea. This evidence concerns the gene ABCB1 and Diarrhea.