Inactive von Hippel-Lindau (VHL) was associated with metabolic reprogramming in clear cell renal cell carcinoma (ccRCC), and it was reported that carcinogenic positive feedback exists between histone lactylation caused by inactive VHL in ccRCC and platelet-derived growth factor receptor β (PDGFRβ) (Yang J. et al., 2022). This evidence concerns the gene VHL and clear cell renal carcinoma.