HK1 and non-small cell lung carcinoma: Jiang et al. found that lactate could down-regulate and up-regulate the expression of glycolytic enzymes (HK-1, PKM) and TCA cycle enzymes (SDHA, IDH3G), respectively, in non-small cell lung cancer (NSCLC), accompanied with the increased histone lactylation (Jiang et al., 2021).