Jiang et al. found that lactate could down-regulate and up-regulate the expression of glycolytic enzymes (HK-1, PKM) and TCA cycle enzymes (SDHA, IDH3G), respectively, in non-small cell lung cancer (NSCLC), accompanied with the increased histone lactylation (Jiang et al., 2021). The gene discussed is PKM; the disease is non-small cell lung carcinoma.