TNF and myeloid sarcoma: Much of the understanding of the pathogenesis of MS is based on studies using the EAE model and it is generally accepted that autoreactive, myelin-specific T cells (T cells which migrate across the blood-brain barrier and mediate damage of neurons and their myelin sheaths) initiate the disease and progression occurs through secretion of proinflammatory cytokines that includes interferon-gamma (IFN-γ), interleukin (IL)-17 and tumor necrosis factor alpha (TNF-α) (19).