In addition, it has been shown to have a hepatoprotective effect against the toxicity of paracetamol and acetaminophen [11, 14], with the treatment of liver diseases achieved through inhibition of cyclooxygenase-II, TNF-α, interleukin-1-beta (IL-1-β), and inducible nitric oxide synthase (iNOS) [15]. The gene discussed is NOS2; the disease is liver disorder.