Only the top second to fourth genes of FBN1, LAMA2 and SPG11 were analyzed in detail, given the consensus of the contribution of NF1 to an autosomal dominant disorder of Type I neurofibromatosis, which was usually complicated with scoliosis (Jett and Friedman, 2010), regardless of ranking first gene of Neurofibromatosis 1 (NF1) for scoliosis high-risk genes. The gene discussed is SPG11; the disease is scoliosis.