Bibliometric analysis based on the reports about AIS risk found that high frequent polymorphism in fibrillin (FBN) gene, estrogen receptor gene, calmodulin, collagen gene and Ladybird Homeobox 1 (LBX1) might involve in physiological or (and) pathological processes, such as menarche, Bone formation, disc degeneration, melatonin signaling dysfunction, and cerebrospinal fluid flow in AIS (Jiang S. et al., 2023). Here, ESR1 is linked to androgen insensitivity syndrome.