Interestingly, one study reported that the overexpression of K18 enhanced the autophagy capacity and sensitivity to oxaliplatin in colorectal cancer HCT116 cells, and it was reversed after the inhibition of the K18 phosphorylation sites (Ser 33/52A), which suggested that the phosphorylation of K18 is involved in apoptosis regulation in cancer cells (69). The gene discussed is KRT18; the disease is colorectal cancer.