KRT8 and neoplasm: downregulated the expression of K8/K18 in oral squamous cell carcinoma derived cell lines and found that K18 may be involved in regulating the expression of cell motion-related protein fascin and α6β4 integrin, as well as the phosphorylation activation of downstream signaling molecules such as FAK, Shc, and ERK1/2 to promote tumor invasion and metastasis (144).