We also confirmed the induction of ER stress and secretion of inflammatory cytokines in the OBP2A-knockdown 3DE-model, and these phenomena are deeply related to dysfunction of desmosomal structure,33,44,45 lamellar body secretion,66 and keratinocyte differentiation,33 which are also observed in atopic dermatitis skin.67 Here, OBP2A is linked to atopic eczema.