Furthermore, doubts to long-term antitumoural efficacy have been implicated: Mistarz et al. [34] isolated CD8+ T-cells from an immunosuppressive CAF environment after depletion of CAFs and tumour regression and found that these had reduced cytotoxic activity compared to wild-type CD8+ T-cells from depleted immunostimulatory CAF TMEs, emphasising potential long-term dysfunction. The gene discussed is CD8A; the disease is neoplasm.