TP53 and neoplasm: Scholars have explored the function of E6*I from many aspects such as the p53 signaling pathway, apoptosis, cell polarity, oxidative stress, inflammatory response, and tumor resistance (Pim and Banks, 1999; Filippova et al., 2009; Pim et al., 2009; Williams et al., 2014; Artaza-Irigaray et al., 2019; Paget-Bailly et al., 2019).