OXT and schizophrenia: A meta-analysis of randomized, placebo-controlled trials examined the efficacy of oxytocin in schizophrenia and found that oxytocin was superior to placebo for the PANSS general psychopathology scale, and was not different from placebo for PANSS total symptoms, positive or negative symptoms.69 However, when the researchers removed the study of Davis et al,28 due to intermittent administration of drug, the meta-analysis found improvement in negative symptoms.