XRN1 and cancer: Finally, there is increasing evidence suggesting that cells may accumulate immunostimulatory dsRNAs when there is a defect in RNA processing and degradation.[84] Therefore, deficiencies in RNA metabolic enzymes, such as Dicer, XRN1 and SKIV2L are linked to the accumulation of dsRNA and type I IFN signaling and might prime cancer cells for a viral mimicry state.[35, 36, 85]