XRN1 and cancer: Indeed, cells that are primed for viral mimicry have been found to depend for their survival on the repressors of dsRNA, including adenosine deaminase acting on RNA (ADAR1) and 5′‐3′‐ exoribonuclease 1 (XRN1).[33, 34, 35, 36] Taken together, these findings suggest that cancer cells that are in a viral mimicry‐primed state may be more sensitive to interventions that disrupt the mechanisms that prevent the accumulation of self‐DNA and ‐RNA and, thus, may be more susceptible to a potential synergy with PARP7i.