Loss of FRA1 promoted an IRF1‐ and IRF3‐dependent induction of type I IFN signaling via the upregulation of the RLR RIG‐1 and melanoma differentiation‐associated protein 5 (MDA5), as well as CASP8‐mediated apoptosis (Figure 1).[19] Taken together, these findings suggest that the PARP7 inhibition‐dependent activation of IRF3, IRF7, and NK‐κB inhibits tumor growth (Figure 1). This evidence concerns the gene IRF3 and neoplasm.