GSDMC and pancreatic ductal adenocarcinoma: Recent reports have linked high expression levels of GSDMC to poor prognosis and impaired immune cell infiltration in pancreatic ductal adenocarcinoma, supporting its role in promoting cancer.[27] However, contrasting findings have shown inhibited GSDMC expression in oesophageal squamous cell carcinoma, suggesting its potential as a tumor suppressor gene.[28] The true role of GSDMC in cancer development remains unclear and requires further investigation.