Furthermore, upregulating GSDM protein expression in tumor cells through gene editing poses challenges.[95, 99] The components necessary for gene editing, such as the Cas9 protein coding sequence and corresponding guide RNA (gRNA), may exceed the loading capacity of commonly used vectors (e.g., adeno‐associated virus (AAV)).[121] This limitation hampers the effective delivery of large vectors. The gene discussed is GSDMA; the disease is neoplasm.