Initially, identified as melanoma‐derived leucine zipper‐containing extranuclear factor (MLZE), it was found to be highly expressed in metastatic melanoma cells.[26] Further investigations revealed that GSDMC undergoes specific cleavage by caspase‐8 upon treatment with tumor necrosis factor‐α (TNFα), leading to the cleavage of the N‐terminal domain of GSDMC. The gene discussed is GSDMC; the disease is metastatic melanoma.