Studies have revealed that signaling molecules and damage‐associated molecular patterns (DAMPs) released during pyroptosis, including high mobility group protein B1 (HMGB1), adenosine triphosphate (ATP), and IL‐1 family cytokines, can recruit immune cells to infiltrate tumors and activate them.[7] In 2020, three pioneering studies collectively established that pyroptosis can enhance the antitumor immune response.[8] These findings indicate that tumor cell‐specific pyroptosis can eliminate tumors and prevent tumor recurrence in preclinical models. Here, HMGB1 is linked to neoplasm.