NGPS is caused by a homozygous A12T point mutation in barrier-to-autointegration-factor 1 (BAF; also known as BANF1), a small protein that binds to DNA, A-type lamins and several nuclear envelope proteins (Cabanillas et al., 2011; Puente et al., 2011). This evidence concerns the gene BANF1 and Nestor-Guillermo progeria syndrome.