A preferential loss of Mag occurs in hypoxic demyelinating lesions in multiple sclerosis (MS) CNS before loss of other myelin proteins such as MBP, PLP, and MOG (Aboul‐Enein et al., 2003), and compact myelin proteins such as Mbp and Plp are preserved in Mag knock out mice (Li et al., 1994). This evidence concerns the gene MOG and multiple sclerosis.