VCP and amyotrophic lateral sclerosis: Like mutations in PrLDs of RBPs, mutations in proteins that facilitate ubiquitin-dependent autophagy, such as VCP and P62, also cause multisystem proteinopathy with several different phenotypes (FTD, ALS, PDB, rimmed vacuolar myopathy) (Ber et al., 2013; Bucelli et al., 2015; Fecto et al., 2011; Hocking et al., 2002; Watts et al., 2004).