It is interesting to note that recessive LMNA mutations can cause a severe EDMD, Lmna knockout in mice results in EDMD and dilated cardiomyopathy phenotypes, and haploinsufficient mice develop a later-onset cardiomyopathy (Chandar et al., 2010; Heller et al., 2020; Kang et al., 2018). This evidence concerns the gene LMNA and Emery-Dreifuss muscular dystrophy.