FHL1 and Emery-Dreifuss muscular dystrophy: Mutations in FHL1 cause several forms of X-linked dominant disorders, including Emery-Dreifuss muscular dystrophy (EDMD), X-linked scapuloperoneal myopathy, reducing body myopathies, rigid spine syndromes and sometimes hypertrophic cardiomyopathy (Quinzii et al., 2008).