Here in our study, we observed that NRG not only inhibited COL1A1 at gene and protein levels, and decreased Ctgf, Acta2, and Serpine1 expression in mouse PCLS, but also show antifibrotic effects in cirrhotic human livers by suppressing COL1A1, PCOL1a1, and gene expression of ACTA2 and SERPINE1 significantly, further supporting the therapeutic potency of NRG in liver fibrosis. This evidence concerns the gene SERPINE1 and Hepatic fibrosis.