As well, in order to explore the mechanism by which SIRT3 influences NSCLC, first, we found that the genes and biological processes that positively correlated with SIRT3 expression in both LUAD and LUSC were mainly involved in the mitochondrial respiration chain complex assembly, NADH dehydrogenase complex assembly, and cytochrome complex assembly, which are all key processes of OXPHOS (Figure 5B–D). Here, SIRT3 is linked to non-small cell lung carcinoma.