TARDBP and amyotrophic lateral sclerosis: 2022). However, it is also conceivable that disease pathways leading to neuropsychological dysfunction may not always have a clear TDP‐43 pathological correlate. Loss of TDP‐43 splicing repression, with the potential translation of cryptic exon‐encoded neopeptides, has been hypothesized as an early or even pre‐symptomatic event in ALS/FTD pathogenesis, even in the absence of overt TDP‐43 pathology (Irwin et al. 2024).