TARDBP and amyotrophic lateral sclerosis: 2021). Puzzlingly though, the same study also identified TDP‐43 pathology in the anterior cingulate cortex (Stages 2 and 3) to be especially associated. An association with generally advanced Brettschneider staging is however consistent with other neuropathological studies emphasizing the importance of TDP‐43 burden in the superior and middle frontal gyrus (Stage 3) (Brettschneider et al. 2012) and hippocampus (Stage 4) (Takeuchi et al. 2016) as possible correlates of cognitive dysfunction in respective ALS cohorts.