TBK1 and amyotrophic lateral sclerosis: 2016; Mccombe et al. 2019). Following TBK1, pathological variants in TARDBP (encoding TDP‐43) and VCP are comparatively rare. About one‐third of ALS patients with pathological variants in TARDBP present with ALSci/ALSbi or ALScbi, generally lacking distinctive cognitive or behavioral impairment compared to sporadic ALS (Moglia et al. 2024). Conversely, less is clear about VCP‐associated ALS, but a review of published cases indicated the predominant phenotype to be ‘classical ALS’ with cognitive or behavioral symptoms reported infrequently (Feng et al. 2022).