Treatment of NB cells with several targeted inhibitors had previously demonstrated ER stress induced cell death facilitated by ATF4 induction, following canonical PERK activation and eIF2α phosphorylation,93 thereby supporting ATF4‐PERK‐eIF2α driven ER stress as a canonical cell death signalling pathway in NB induced by the combination of SGC0946 and GSK343. The gene discussed is EIF2A; the disease is neuroblastoma.