We used the publically available data from two (Kocak53 and SEQC54) large NB patient primary tumour total mRNA databases to confirm the findings of previous studies that high expression of either EZH2 or DOT1L, dichotomised around their median expression level, correlated with poor NB patient prognosis (Figure S3A–D).11, 55, 56, 57. This evidence concerns the gene EZH2 and neuroblastoma.