In 56/126 (45%) cases, the ALOX12B gene was involved, making it the most common cause of ARCI in the tested population, while in 33/126 (26%) and 18/126 (14%) of cases the TGM1 and ALOXE3 genes were causal, respectively. The gene discussed is TGM1; the disease is autosomal recessive congenital ichthyosis.